Based on theory and human research, a number of drugs may deplete natural levels of CoQ10 in the body.

Diabetes drugs - tolazamide, tolbutamide, acetohexamide; methyldopa; clonidine; gemfibrozil; tricyclic such as chlorpropamide, glimepiride, glipizide, glyburide, metformin

Antidepressant drugs - such as amitriptyline, clomipramine, doxepin, imipramine, trimipramine.

Antipsychotic medications - such as chlorpromazine, fluphenazine, haloperidol, mesoridazine, prochlorperazine, promethazine, thioridazine, trifluoperazine, trimipramine

Beta-blockers (high blood pressure) - such as acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, esmolol, labetalol, metoprolol, nadolol, penbutolol, pindolol, propanolol, sotalol, timolol

HMG-CoA reductase inhibitors (Statins) - such as atorvastatin (lipitor), cerivastatin (no longer available in U.S.), fluvastatin, lovastatin, pravastatin, simvastatin

Diuretics (water pills) - such as benzthiazide, hydralazine, chlorthiazide, hydrochlorothiazide, indapamide, methyclothiazide, metolazone, polythiazide.

http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-coenzymeq10.html